Juvederm

Juvederm is a family of injectable hyaluronic acid dermal fillers used to provide 9 months to one year of correction for moderate to severe facial wrinkles and folds, such as nasolabial folds (lines from the nose to the corners of the mouth).

It is not indicated for use in lip augmentation.

Juvederm products are a smooth consistency gel, compared to some hyaluronic gel products that have a granular consistency.

Juvederm products are developed using the Hylacross technology to allow a smoother, malleable gel.

Hyaluronic acid is a naturally occurring sugar found in the body.

Hyaluronic acid works by holding in water at the injection site and acting as a cushioning agent.

It adds temporary volume and a smoother appearance to skin. Most patients only need one treatment to achieve optimal results.

Juvederm Clinical Trials

In the two primary U.S. clinical studies evaluating Juvederm Ultra or Juvederm Ultra Plus for safety and effectiveness, roughly 145 subjects were followed for 24 weeks after the Juvederm injection in one nasolabial fold.

Compared to Zyplast dermal filler (bovine-based collagen) which was injected into the opposite nasolabial fold, Juvederm injection site reactions were similar in duration and frequency, mild to moderate in severity, did not require intervention, and typically lasted about 7 days.

Redness, pain/tenderness, firmness, swelling and lumps/bumps occurred in roughly 80-90% of patients, bruising in 60% of patients, and itching and discoloration in roughly 35% of patients.

The percent of patients who maintained improvement with Juvederm at 24 weeks was 88-90% compared to 36-40% with Zyplast.

At study end, 84-88% of the patients expressed a preference for Juvederm Ultra injectable gel, 5-10% had a preference for Zyplast, and 5-6% of patients had no preference.

Of 146 subjects, 111-116 (76-79%) returned for a complimentary repeat treatment at an average of 36 weeks after their last injection. Forty-eight subjects returned after 36 weeks.

Subjects who maintained improvement with Juvederm Ultra injectable gel was 75-81%.

Patients rated their improvement prior to injection as mainly mild to moderate (between 1 and 2 on a scale going from 0 [no improvement] to 4 [extreme improvement]) from 2 weeks until greater than 36 weeks after injection.

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